12. Therapeutic Potential of the Chimeric Adenovirus 5/40 as Vector for Intestine-Directed Gene Therapy
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اول[Development of pegylated adenovirus vector for cancer gene therapy].
Adenovirus vectors (Ad) have been frequently used for cancer gene therapy research because of their high gene transduction efficiency. However, systemic administration of conventional Ad can lead to the acute accumulation of virus particles and transgene expression in the liver, which may cause severe hepatotoxicity. For these reasons, clinical application of Ad for systemic administration has ...
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متن کاملBiology of adenovirus and its use as a vector for gene therapy.
ADENOVIRUSES WERE FIRST DISCOVERED half a century ago by Rowe and colleagues, who were trying to culture adenoid tissue in the laboratory (Rowe et al., 1953). Since that time, nonhuman adenoviruses have been isolated from a number of species including chimpanzees, pig, mouse, and dog, as well as other mammalian and avian species (Shenk, 1996). Although human adenoviruses cause significant level...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2006
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2006.08.023